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Selected Publications in Biothermal Technology

       Ehrlich, L.E., Malen, J.A., Rabin, Y. (2016): Thermal conductivity of the cryoprotective cocktail DP6 in cryogenic temperatures, in the presence and absence of synthetic ice modulators, Cryobiology, 73(2):196-202 ScienceDirect

       Feig, J.S.G., Solanki, P.K., Eisenberg, D.P., Rabin, Y. (2016): Polarized light scanning cryomacroscopy, Part II: thermal modeling and analysis of experimental observations, Cryobiology, 73(2):272-281 PubMed

       Feig, J.S.G., Eisenberg, D.P., Rabin, Y. (2016): Polarized light scanning cryomacroscopy, Part I: Experimental apparatus and observations of vitrification, Crystallization, and Photoelasticity Effects, Cryobiology, 73(2):261-71 PubMed

       Sehrawat, A., Keelan, R., Shimada, K., Wilfong, D.M., McCormick, J.T., Rabin, Y. (2016): Simulation-based cryosurgery training: variable insertion-depth planning in prostate cryosurgery, Technology in Cancer Research and Treatment, 15(6):805-814 PubMed

       Lee, J.E., Ozdoganlar, O.B., Rabin, Y. (2016): Experimental Validation for A Thermal Model of the Temperature Distributions During Bone Drilling, ASME 2016 International Mechanical Engineering Congress & Exposition, Phoenix, AZ (November 11-17)

       Sehrawat, A., Keelan, R., Shimada, K., Wilfong, D.M., McCormick, J.T., Rabin, Y. (2016): Simulation-based cryosurgery intelligent tutoring system (ITS) prototype, Technology in Cancer Research and Treatment, 15(2):396-407 PubMed

       Keelan, R., Zhang, H., Shimada, K., Rabin, Y. (2016):  GPU-based bioheat simulation to facilitate rapid decision making associated with cryosurgery training, Technology in Cancer Research and Treatment 15(2): 377-386 PubMed

       Lewis, J.K., Bischof, J.C., Braslavsky, I., Brockbank, K.G., Fahy, G.M., Fuller, B.J., Rabin, Y., Tocchio, A., Woods, E.J., Wowk, B.G., Acker, J.P., Giwa, S. (2016): The Grand Challenges of Organ Banking: Proceedings from the first global summit on complex tissue cryopreservation, Cryobiology 72(2):169-82 ScienceDirect

       Keelan, R., Shimada, K., Rabin, Y. (2015): GPU-based simulation of ultrasound imaging artifacts for cryosurgery training, Technology in Cancer Research and Treatment, DOI: 10.1177/1533034615623062 PubMed

       Ehrlich, L.E., Malen, J.A., Rabin, Y. (2015): Thermal Conductivity Measurements of Cryoprotectants at Low Temperatures. ASME 2015 International Mechanical Engineering Congress & Exposition, Houston, Texas (November 13-19)

       Eisenberg, D.P., Bischof, J.C., Rabin, Y. (2015): Thermo-mechanical stress in cryopreservation via vitrification with nanoparticle heating as a stress-moderating effect, ASME Journal of Biomechanical Engineering, 138(1), doi: 10.1115/1.4032053 Pubmed

       Thaokar, C., Rossi, M.R., Rabin, Y. (2015): A new method for temperature-field reconstruction during ultrasound-monitored cryosurgery using potential-field analogy, Cryobiology, 72(1):69–77 PubMed

       Ehrlich, L.E., Feig, J.S.G., Schiffres, S.N., Malen, J.A., Rabin, Y. (2015): Large thermal conductivity differences between the crystalline and vitrified state of DMSO with applications to cryopreservation, PlosONE 80. 

       Eisenberg, D.P., Rabin, Y. (2015): Stress-strain measurements in vitrified arteries permeated with synthetic ice modulators, ASME Journal of Biomechanical Engineering, in press 137(8) PubMed

       Eisenberg, D.P., Steif, P.S., Rabin, Y. (2014): On the effects of thermal history on the development and relaxation of thermo-mechanical stress in cryopreservation, Cryogenics, 64:86–94 PubMed

       Furuhata, T., Song, I., Rabin, Y., Shimada, K. (2014): Interactive prostate shape reconstruction from 3D TRUS images, Journal of Computational Design and Engineering, 1(4):272-288 Download

       Khairi, A., Thaokar, C., Fedder, G., Paramesh, J., Rabin, Y. (2014): Characterization of a CMOS sensing core for ultra-miniature wireless implantable temperature sensors with application to cryomedicine, Medical Engineering and Physics, 36(9):1191–1196 PubMed

       Feig, J.S.G., Rabin, Y. (2014):  The scanning cryomacroscope with applications to cryopreservation – a device prototype, Cryogenics, 62:118–128 PubMed

       Eisenberg, D.P., Taylor, M.J., Jorge L. Jimenez-Rios, Rabin, Y. (2014): Thermal expansion of vitrified blood vessels permeated with DP6 and synthetic ice modulators, Cryobiology, 68(3):318-26 PubMed

       Feig, J.S.G., Rabin, Y. (2013):  Integration of polarized light into scanning cryomacroscopy. CRYO2013-the 50th  Annual Meeting of the Society for Cryobiology, N. Bethesda, DC (July 28-31), Cryobiology, 67(3):399-400 ScienceDirect

       Rabin, Y., Taylor, M.J., Feig, J.S.G., Baicu, S., Chen, Z. (2013): A new cryomacroscope device (Type III) for visualization of physical events in cryopreservation with applications to vitrification and synthetic ice modulators, Cryobiology 67(3):264-73 PubMed

       Keelan, R., Yamakawa, S., Shimada, K., Rabin, Y. (2013): Computerized Training of cryosurgery – a system approach, CryoLetters 34(4):324-337 PubMed

       Khairi, A., Wu, C, Rabin, Y., Fedder, G., Paramesh, J., Schwartzman, D. (2013): Ultra-low power frequency and duty-cycle modulated implantable temperature-pressure sensor. IEEE Biomedical Circuits and Systems Conference - BioCAS 2013, IEEE, pp. 226-229, Rotterdam, the Netherlands (October 31 – November 2)

       Ehrlich, L.E., Feig, J.S.G., Schiffres, S.N., Malen, J.A., Rabin, Y. (2013): A new device and technique for thermal conductivity measurements of glass-forming materials with application to cryopreservation. ASME 2013 Summer Bioengineering Conference - SBC 2013, Minneapolis, MN, USA (July 14-19)

       Rabin, Y., Feig, J.S.G., Williams, A.C., Lin, C.C., Thaokar, C. (2012): Cryomacroscopy in 3D: a device prototype for the study of cryopreservation. ASME 2012 Summer Bioengineering Conference - SBC 2012, Fajardo, Puerto Rico, USA (June 20-23) Download

       Sehrawat, A., Shimada, K., Rabin, Y. (2012): Generating prostate models by means of geometric deformation for the application of computerized training of cryosurgery. International Journal of Computer Assisted Radiology and Surgery, 8(2): 301-312 Download

       Thaokar, C., Rabin, Y. (2012): Temperature field reconstruction for the application of wireless implantable temperature sensors in cryosurgery, Cryobiology 65(3):270-277 PubMed

       Eisenberg, D.P., Taylor, M.J., Rabin, Y. (2012): Thermal expansion of DP6 combined with synthetic ice blockers in presence and absence of biological tissues. Cryobiology, 65(2):117-125 PubMed

       Lee, J.E, Ozdoganlar, O.B., Rabin, Y.  (2012): An experimental investigation on thermal exposure during bone drilling. Medical Engineering and Physics, 34:1510-1520 Download

       Lee, J.E, Rabin, Y., Ozdoganlar, O.B. (2011): A new thermal model for bone drilling with applications to orthopaedic surgery. Medical Engineering and Physics, 33(10):1234-44 Download

       Lee, J.E., Ozdoganlar, O.B., Rabin, Y. (2011): Analysis of heat transfer in bone drilling. ASME 2011 Summer Bioengineering Conference - SBC 2011, Farmington, PA, USA (June 22-25)

       Eisenberg, D.P., Rabin, Y. (2011): The effect of synthetic ice blockers on thermal expansion of the cryoprotective cocktail DP6. ASME 2011 Summer Bioengineering Conference - SBC 2011, Farmington, PA, USA (June 22-25)

       Keelan, R., Shimada, K., Rabin, Y. (2011): Developing a framework for computerized training of cryosurgery based on finite elements analysis. ASME 2011 Summer Bioengineering Conference - SBC 2011, Farmington, PA, USA (June 22-25)

       Thaokar, C., Rabin, Y. (2011): Temperature field reconstruction for the application of wireless implantable temperature sensors in cryosurgery. ASME 2011 Summer Bioengineering Conference - SBC 2011, Farmington, PA, USA (June 22-25)

       Sehrawat, A., Shimada, K., Rabin, Y. (2011): Geometric deformation of three-dimensional prostate model with applications to computerized training of cryosurgery. ASME 2011 Summer Bioengineering Conference - SBC 2011, Farmington, PA, USA (June 22-25)

       Khairi, A., Hung, S-C, Paramesh, J., Fedder, G., Rabin, Y. (2011): Ultra-miniature wireless temperature sensor for thermal medicine applications. Energy-based Treatment of Tissue and Assessment VI, SPIE – BiOS 2011, San Francisco, CA, USA (January 22-27) Link

       Rossi, M.R., Tanaka, D., Shimada, K., Rabin, Y. (2010): Computerized planning of prostate cryosurgery using variable cryoprobe insertion depth. Cryobiology 60(1):71-79 PubMed

       Rabin, Y. (2009): Computerized planning of cryosurgery: from model reconstruction to cryoprobe placement strategies. BiOS 2009, Energy-based Treatment of Tissue and Assessment V, San Jose, CA, USA (January 24-29) Download

       Noday, D.A., Steif, P.S., Rabin, Y. (2009): Viscosity of cryoprotective agents near glass transition: a new device, technique, and data on DMSO, DP6, and VS55. Journal of Experimental Mechanics, 49(5):663-672 Download

       Steif, P.S., Noday, D.A., Rabin, Y. (2009): Can thermal expansion differences between cryopreserved tissue and cryoprotective agents alone cause cracking? CryoLetters 30(6):414-421 PubMed

       Baicu, S., Taylor, M.J., Chen, Z., Rabin, Y. (2008): Cryopreservation of carotid artery segments via vitrification subject to marginal thermal conditions: Correlation of freezing visualization with functional recovery. Cryobiology, 57(1):1-8 Download

       Rossi, M.R., Tanaka, D., Shimada, K., Rabin, Y. (2008): Computerized planning of cryosurgery using bubble packing: an experimental validation on a phantom material. International Journal of Heat and Mass Transfer 51(23-24):5671-5678 Download

       Tanaka, D., Shimada, K., Rossi, M.R., Rabin, Y. (2008): Computerized planning of prostate cryosurgery with pullback procedure. Computer Aided Surgery, 13(1):1-13 PubMed

       Tanaka, D., Shimada, K., Rossi, M.R., Rabin, Y. (2008): Cryosurgery planning using bubble packing in 3D. Computer Methods in Biomechanics and Biomedical Engineering, 11(2):113-121 Download

       Rabin, Y. (2008): Key issues in bioheat transfer simulations for the application of cryosurgery planning. Cryobiology, 56(3):248-50 Download

       Steif, P.S., Palastro, M.C, Rabin, Y. (2008): Continuum mechanics analysis of fracture progression in the vitrified cryoprotective agent DP6. ASME Biomechanical Engineering, 130(2):021006 PubMed

       Rossi, M., Rabin, Y. (2007): Analysis of a numerical scheme for bioheat simulations of cryosurgery and its experimental validation on a phantom material. MSV'07-The 2007 International Conference on Modeling, Simulation and Visualization Methods, Las Vegas, Nevada (June 25-28) Download

       Zhang, S., Yang, Y., Rabin, Y., Barmak K., Asheghi, M. (2007): A novel experimental procedure and technique for small scale calorimetry. ASME-JSME Thermal Engineering Summer Heat Transfer Conference, HT2007-32894, Vancouver, British Columbia, Canada (July 8-12) Link

       Rossi, M.R., Tanaka, D., Shimada, K., Rabin, Y. (2007): An efficient numerical technique for bioheat simulations and its application to computerized cryosurgery planning. Computer Methods and Programs in Biomedicine, 85(1):41-50 Download

       Jimenez Rios, J.L., and Rabin, Y. (2007): A new device for mechanical testing of blood vessels at cryogenic temperatures. Journal of Experimental Mechanics 47:337–346 (Special issue on: Mechanics of Organic, Implant, and Bioinspired Materials) Download

       Tanaka, D., Rossi, M.R., Shimada, K., Rabin, Y. (2007): Towards intra-operative computerized planning of prostate cryosurgery. The International Journal of Medical Robotics and Computer Assisted Surgery, 3:10-19 Download

       Rossi, M.R., Rabin, Y. (2007): Experimental verification of numerical simulations of cryosurgery with application to computerized planning. Physics in Medicine and Biology 52:4553-4567 Download

       Steif, P.S., Palastro, M.C, Rabin, Y. (2007): The effect of temperature gradients on stress development during cryopreservation via vitrification. Cell Preservation Technology 5(2):104-115 Download

       Zhang, S., Rabin, Y., Yang, Y., Barmak, K., Asheghi, M. (2007): Nanoscale calorimetry using a suspended bridge configuration. IEEE Journal of Microelectromechanical Systems 16(14):861-871 Download

       Jimenez Rios, J.L., Paul S. Steif, and Rabin, Y. (2007): Stress-strain measurements and viscoelastic response of blood vessels cryopreserved by vitrification. Annals of Biomedical Engineering 35(12):2077-2086 Download

       Tanaka, D., Shimada, K., Rabin, Y. (2006): Two-phase Computerized Planning of Cryosurgery Using Bubble-packing and Force-field Analogy. ASME Journal of Biomechanical Engineering, 128(1):49-58 Download

       Jimenez Rios, J.L., Rabin, Y. (2006): Thermal expansion of blood vessels in low cryogenic temperatures, Part I: A new experimental device. Cryobiology, 52(2):269-283 Download

       Jimenez Rios, J.L., and Rabin, Y. (2006): Thermal expansion of blood vessels in low cryogenic temperatures, Part II: Measurements of blood vessels vitrified with VS55, DP6, and 7.05M DMSO. Cryobiology, 52(2):284-294 Download

       Rabin, Y., Steif, P.S., Hess, K.C., Jimenez-Rios, J.L., Palastro, M.C. (2006): Fracture formation in vitrified thin films of cryoprotectants. Cryobiology, 53:75-95 Download

       Baicu, S., Taylor, M.J., Chen, Z., Rabin, Y. (2006): Vitrification of carotid artery segments: An integrated study of thermophysical events and functional recovery towards scale-up for clinical applications. Cell Preservation Technology, 4(4):236-244 Download

       Steif, P.S., Palastro, M.C, Rabin, Y. (2006): Analysis of the effect of partial vitrification on stress development in cryopreserved blood vessels. Medical Engineering & Physics, 29(6):661-670 Download

       Rabin, Y., Steif, P.S. (2006): Solid mechanics aspect of cryobiology, In: Advances in Biopreservation (Baust, J.G., and Baust J.M., Eds.), CRC Taylor & Francis, Chap. 13, pp. 359-382

       Rabin, Y., Plitz, J. (2005): Thermal expansion of blood vessels and muscle specimens permeated with DMSO, DP6, and VS55 in cryogenic temperatures. Annals of Biomedical Engineering, 33(9):1213 – 1228 Download

       Rabin, Y., Taylor, M.J., Walsh, J.R., Baicu, S., Steif, P.S. (2005): Cryomacroscopy of vitrification, Part I: A prototype and experimental observations on the cocktails VS55 and DP6. Cell Preservation Technology, 3(3):169-183 Download

       Steif, P.S., Palastro, M., Wen, C.R., Baicu, S., Taylor, M.J., Rabin, Y. (2005): Cryomacroscopy of vitrification, Part II: Experimental observations and analysis of fracture formation in vitrified VS55 and DP6. Cell Preservation Technology, 3(3):184-200 Download

       Rabin, Y., Steif, P.S. (2005): Letter-to-the-Editor: Analysis of thermo-mechanical stress in cryopreservation. CryoLetters, 26(6):409-411 Download

       Lung, D.C., Stahovich, T.F., Rabin, Y. (2004): Computerized planning for multiprobe cryosurgery using a force-field analogy. Computer Methods in Biomechanics and Biomedical Engineering, 7(2):101-110 Download

       Rabin, Y., Lung, D.C., Stahovich, T.F. (2004): Computerized planning of cryosurgery using cryoprobes and cryoheaters. Technology in Cancer Research and Treatment, 3(3):227-243. Download

       Plitz, J., Rabin, Y., Walsh, J., (2004): The effect of thermal expansion of ingredients on the cocktails VS55 and DP6. Cell Preservation Technology, 2(3):215-226 Download

       Zhang, S., Yang, Y., Barmak, K., Rabin, Y., Asheghi, M. (2004): MEMS based high sensitivity calorimetry. International Mechanical Engineering Congress and Exposition 2004, Anaheim, CA (November 13-19) Download

       Rabin, Y., Stahovich, T.F. (2003): Cryoheater as a means of cryosurgery control. Physics in Medicine and Biology, 48:619-632 Download

       Rabin, Y. (2003): A general model for the propagation of uncertainty in measurements into heat transfer simulations and its application to cryobiology. Cryobiology, 46(2):109-120 Download

       Rabin, Y., Bell, E. (2003): Thermal expansion measurements of cryoprotective agents. Part I: A new experimental apparatus. Cryobiology, 46(3):254-263 Download

       Rabin, Y., Bell, E., (2003): Thermal expansion measurements of cryoprotective agents. Part II: Measurements of DP6 and VS55, and comparison with DMSO. Cryobiology, 46(3):264-270 Download

       Rabin, Y. (2002): Is intracellular hyperthermia superior to extracellular hyperthermia in the thermal sense? International Journal of Hyperthermia, 18(3):194-202 Download

       Rabin, Y., Stahovich, T.F. (2002): The thermal effect of urethral warming during cryosurgery. CryoLetters, 23:361-374 Download

       Rabin, Y. (2001): Imaging of breast cryosurgery. In: Atlas of Cryosurgery (Korpan, N.K., Ed.), Springer-Verlag, Vienna, Austria, pp. 344-353 Download

       Rabin, Y., Julian, T.B., Olson, P. (2001): Minimally invasive breast cryosurgery. In: Basics of Cryosurgery (Korpan, N.K., Ed.), Springer-Verlag, Vienna, Austria, pp. 213-223 Download

       Rittel, D., Rabin, Y. (2000): An investigation of the heat generated during cyclic loading of two glassy polymers, Part II: thermal analysis. Mechanics of Materials, 32(3):149-159 Download

       Rabin, Y., Steif, P.S. (2000): Thermal stress modeling in cryosurgery. International Journal of Solids and Structures 37:2363-2375 Download

       Rabin, Y., Rittel, D. (2000): Infrared temperature sensing of mechanically loaded specimens: thermal analysis. Experimental Mechanics, 40(2):197-202 Download

       Rabin, Y. (2000): The effect of temperature-dependent thermophysical properties in heat transfer simulations of biomaterials in cryogenic temperatures. Cryo-Letters, 21:163-170 Download

       Rabin, Y., Podbilewicz, B. (2000): Temperature-controlled microscopy for 4-D imaging of living cells: apparatus, thermal analysis, and temperature dependency of embryonic elongation in C. elegans. Journal of Microscopy, 199(3): 214-223 Download

       Rabin, Y. (2000): Is it reasonable to assume a uniformly distributed cooling rate along the microslide of a directional solidification stage? Journal of Microscopy, 200(1):42-49 Download

       Dennis, B.H., Dulikravich, G.S., Rabin, Y. (2000): Optimization of organ freezing protocols with specified allowable thermal stress levels. International Mechanical Engineering Congress and Exposition 2000, Orlando, FL, November 5-10, HTD-Vol. 368/BED-Vol. 47, pp. 33-48 Download

       Rabin, Y., Julian, T.B., Olson, P., Taylor, M.J., Wolmark, N. (1999): Cryosurgery for breast malignancies: apparatus and techniques. In: Advances in Heat and Mass Transfer in Biotechnology, International Mechanical Engineering Congress and Exposition 1999, Nashville, Tennessee. HTD-Vol. 363, BED-Vol. 44, pp. 65-69 Download

       Rabin, Y., Maytal, B-Z. (1999): Thermal analysis of cryocycling. Cryo-Letters, 20(2):95-102 Download

       Rabin, Y., Rittel, D. (1999): A model for the time response of solid-embedded thermocouples. Experimental Mechanics, 39(1):132-137 Download

       Rabin, Y., Julian, T.B., Olson, P., Taylor, M.J., Wolmark, N. (1999): Long-term follow-up post-cryosurgery in a sheep breast model. Cryobiology, 39:29-46 Download

       Rabin, Y., Steif, P.S. (1999): Thermal stress modeling of freezing biological tissues. In: Advances in Heat and Mass Transfer in Biotechnology, International Mechanical Engineering Congress and Exposition 1999, Nashville, Tennessee. HTD-Vol. 363, BED-Vol. 44, pp. 183-188 Download

       Rabin, Y., Julian, T.B., Olson, P., Taylor, M.J., Wolmark, N. (1999): Development of a cryosurgical technique for breast malignancies. SPIE Conference on Innovations in Breast Cancer Diagnosis and Minimally Invasive Therapy, San Jose, CA (January 23-29). SPIE 3590:465-471. Link

       Rabin, Y., Shitzer, A. (1998): Numerical solution of the multidimensional freezing problem during cryosurgery. ASME Journal of Biomechanical Engineering, 120(1):32-37 Download

       Rabin, Y. (1998): Uncertainty in temperature measurements during cryosurgery, Cryo-Letters, 19(4):213-224 Download

       Rabin, Y., Taylor, M.J., Wolmark, N. (1998): Thermal expansion measurements of frozen biological tissues at cryogenic temperatures. ASME Journal of Biomechanical Engineering, 120(2):259-266 Download

       Rabin, Y., Julian, T.B., Olson, P., Taylor, M.J., Wolmark, N. (1998): Evaluation of post cryosurgery injury in a sheep breast model using the vital stain 2,3,5-triphenyltetrazolium chloride. Cryo-Letters, 19(4):255-262 Download

       Rabin, Y., Steif, P.S. (1998): Thermal stresses in a freezing sphere and its application to cryobiology. ASME Journal of Applied Mechanics, 65(2):328-333 Download

       Rabin, Y. (1998): Uncertainty in measurements of fluid temperature in tubes. Cryo-Letters, 19(5):319-326 Download

       Rabin, Y., Shitzer, A. (1997): Combined solution to the inverse Stefan problem for successive freezing/thawing in non-ideal biological tissues. ASME Journal of Biomechanical Engineering, 119(2):146-152 Download

       Rabin, Y., Julian, T.B., Wolmark, N. (1997): A compact cryosurgical apparatus for minimal-invasive cryosurgery. Biomedical Instrumentation & Technology, 31:251-258 Download

       Rabin, Y., Olson, P., Taylor, M.J., Steif, P.S., Julian, T.B., Wolmark, N. (1997): Gross damage accumulation in frozen rabbit liver due to mechanical stress at cryogenic temperatures. Cryobiology, 34:394-405 Download

       Rabin, Y., Shitzer, A. (1996): A new cryosurgical device for controlled freezing, Part I: setup and validation test. Cryobiology, 33:82-92 Download

       Rabin, Y., Coleman, R., Mordohovich, D., Ber, R., Shitzer, A. (1996): A new cryosurgical device for controlled freezing, Part II: in vivo experiments on rabbits’ hind thighs. Cryobiology, 33:93-105 Download

       Rabin, Y., Steif, P.S. (1996): Analysis of thermal stresses around a cryosurgical probe. Cryobiology, 33:276-290 Download

       Rabin, Y., Steif, P.S., Taylor, M.J., Julian, T.B., Wolmark, N. (1996): An experimental study of the mechanical response of frozen biological tissues at cryogenic temperatures. Cryobiology, 33:472-482 Download

       Rabin, Y., Shitzer, A. (1995): Exact solution to the one dimensional inverse Stefan problem in non-ideal biological tissues. ASME Journal of Heat Transfer, 117(2):425-431 Download

       Rabin, Y., Korin, E. (1993): An efficient numerical solution for the multidimensional solidification (or melting) problem using a microcomputer. International Journal of Heat and Mass Transfer, 36(3):673-683 Download

 

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