42-101 Intro
to BME - Fall 2005
WORKING SYLLABUS
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|
Day |
Date |
Topics |
Reading Reading
Links |
Activity |
|
M |
10 Jan |
Introductions & Course Organization |
MMD: Chapter 0 |
|
|
W |
12 |
0. Background Material 0.a units and dimensions in equations 0.b dimensionless groups 0.c accuracy and precision |
new team org sheet due in class |
|
|
F |
14 |
0.d quantifying precision |
|
Jung type test results due to Todd via email |
|
M |
17 |
ML
King Day – No Class |
|
|
|
W |
19 |
0.e propagating precision/error 1. Building Blocks of Living Systems 1.a basic microbiology: prokaryotes, eukaryotes |
Course
Notes: MMD: Chapter 1 |
|
|
F |
21 |
1.b cellular composition: elemental and
molecular Add Deadline |
PS #1 due in class |
|
|
M |
24 |
1.c water 1.d building blocks and macromolecules: lipids 1.d building blocks and macromolecules: amino
acids and proteins |
|
|
|
W |
26 |
1.d building blocks and macromolecules: carbohydrates 1.d
building blocks and macromolecules:
nucleotides and nucleic acids 1.e information flow: The Central Dogma, the
genetic code, protein expression |
|
interim team evaluation in class for Block A |
|
F |
28 |
1.f cellular stoichiometry class
cancelled while Todd deals with flu |
|
PS #2 due in class |
|
M |
31 |
1.f cellular stoichiometry - redux |
|
|
|
W |
2 Feb |
2. Mass Balancing and Kinetics in Living
Systems 2.a general mass balance expressions for open and closed systems 2.b organizational strategy for solving mass balance problems 2.c solving mass balance problems: tracer example 2.d solving mass balance problems: cellular
stoichiometry example |
MMD: Chapter 2 |
|
|
F |
4 |
2.d solving mass balance problems: cellular
stoichiometry example (cont’d) |
|
PS #3 due in class |
|
M |
7 |
Mid-Mini
Break - No Class |
|
|
|
W |
9 |
2.d mass balance problems with recycle, purge and bypass: human Fe inventory example, parametric study and operating diagram extension |
Course
Notes |
|
|
F |
11 |
2.e unsteady mass balances & kinetics: microbial growth 2.f coupled mass balances and kinetics: microbial growth and substrate usage |
|
PS #4 due in class |
|
M |
14 |
2.g unsteady mass balances: pharmacokinetics
examples |
|
Final team evaluation for Block A (complete on own, turn in in class) |
|
W |
16 |
Midterm
Exam No. 1 (note 2 hours) AIMBE |
|
|
|
F |
18 |
3. Living
Systems as Engineering Systems 3.a engineering systems 3.b acceleration of reactions: enzymatic catalysis 3.c
energy coupling |
MMD: Chapter 3 |
new team org sheet due in class |
|
M |
21 |
3.d communication and control: control
strategies |
|
|
|
W |
23 |
3.e human blood pressure control 3.f reckoning signal flow in control NYSTAR panel |
|
|
|
F |
25 |
4. Bioenergetics 4.a reckoning energy and power 4.b forms of energy 4.c macroscopic energy balances for open and closed systems 4.d macroscopic energy balance examples |
MMD: Chapter 4 |
PS #5 due in class |
|
M |
28 |
4.e cellular energy transduction:
substrate-level ATP formation |
|
|
|
W |
2 Mar |
4.f cellular energy transduction: oxidative-level ATP formation (chemiosmotic hypothesis) |
|
interim team evaluation in class for Block B |
|
F |
4 |
Spring
Break - No Class Whitaker Summit |
|
|
|
M |
7 |
Spring
Break - No Class |
|
|
|
W |
9 |
Spring
Break - No Class |
|
|
|
F |
11 |
Spring
Break - No Class |
|
|
|
M |
14 |
5. Binding 5.a binding specificity 5.b binding kinetics and thermodynamics |
MMD: Chapters 5
and 6 |
|
|
W |
16 |
5.c binding contexts: recognition 5.d binding contexts: enzymatic catalysis |
|
|
|
F |
18 |
5.e binding contexts: control and enzyme inhibition |
|
PS #6 due in class |
|
M |
21 |
5.f practice problems ST |
|
|
|
W |
23 |
Midterm
Exam No. 2 (note 2 hours) ST |
|
|
|
F |
25 |
6. Basic Physiological
Systems 6.a “The Electric Heart” ST |
MMD Chapter 9 |
|
|
M |
28 |
6.b the Standard Man 6.c digestive system 6.d cardiovascular system Drop
Deadline |
|
|
|
W |
30 |
6.e lymph system 6.f renal system 6.g endocrine system |
Course
Notes |
|
|
F |
1 Apr |
7. Biomechanics 7.a ambulation model |
MMD Chapter 10 |
PS #7 due in class |
|
M |
4 |
7.b stride optimization
7.c ergonomic analysis |
|
|
|
W |
6 |
8. Biofluid Mechanics 8.a fluid properties 8.b hydrostatics 8.c. inviscid flow |
MMD Chapter 11 |
|
|
F |
8 |
8.d viscous flow (of Newtonian fluid) |
|
PS #8 due in class |
|
M |
11 |
8.e blood rheology |
|
Final team evaluation for Block B (complete on own, turn in in class) |
|
W |
13 |
Midterm
Exam No. 3 (note 2 hours) |
|
|
|
F |
15 |
Spring Carnival – No Class |
|
|
|
M |
18 |
8.g blood hydrostatics and hydrodynamics examples |
|
new team org sheet due in class |
|
W |
20 |
9. Biomaterials and Tissue
Engineering 9.a materials properties 9.b body response to implanted materials |
MMD Chapter 12 |
|
|
F |
22 |
9.c blood clotting |
|
PS #9 due in class |
|
M |
25 |
10. Biomedical Imaging 10.a non-invasive imaging modalities |
MMD Chapter 14 |
interim team evaluation in class for Block C |
|
W |
27 |
10.b magnetic resonance imaging basics 10.c basic signal processing concepts Midterm exam makeup 2:25-4:25 Doherty Hall 2100 |
|
|
|
F |
29 |
11. Biomedical Engineering
Re-Overview Last
Day of Class |
PS #10 due in class Final team evaluation for Block C (complete on own, turn in in class) |
|
|
Th |
5 May |
Final
Exam Time:
1:00 pm – 4:00 pm Location:
DH 2315 NO
MAKE UP FINAL GIVEN |
|
|
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Last updated 4/30/05 by TMP