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Ultra-Miniature Wireless Implantable Temperature Sensors


This line of research focuses on the development of ultra-miniature wireless implantable temperature sensors, for the purpose of evaluation and control of thermal surgery. Thermal surgery is the destruction of cancerous tumors by freezing (i.e., cryosurgery) or by heating (hyperthermia at moderate temperatures and thermal ablation at higher temperatures). Thermal surgery is a minimally invasive procedure, where its success is dependent upon the ability to measure temperatures at critical locations and reconstruct the temperature field in real time.


The goal in this line of research is to make temperature-field reconstruction in real time a practical reality. The groundbreaking conceptual design of the new temperature-sensing unit originates from recent advances in electronics fabrication, miniaturization, and wireless communication. The sensing-unit consists of three main components: a temperature-sensing core, a wireless transceiver, and a power link. Below is a picture of a 0.1 mm × 0.4 mm CMOS temperature sensing core:




Selected publications:

       Khairi, A., Thaokar, C., Fedder, G., Paramesh, J., Rabin, Y. (2014): Characterization of a CMOS sensing core for ultra-miniature wireless implantable temperature sensors with application to cryomedicine, Medical Engineering and Physics, 36(9):1191–1196 PubMed, HHS Public Access, ScienceDirect

       Khairi, A., Wu, C, Rabin, Y., Fedder, G., Paramesh, J., Schwartzman, D. (2013): Ultra-low power frequency and duty-cycle modulated implantable temperature-pressure sensor. IEEE Biomedical Circuits and Systems Conference - BioCAS 2013, IEEE, pp. 226-229, Rotterdam, the Netherlands (October 31 – November 2) IEEE Xplore

       Thaokar, C., Rabin, Y. (2012): Temperature field reconstruction for the application of wireless implantable temperature sensors in cryosurgery, Cryobiology 65(3):270-277 PubMed, HHS Public Access, ScienceDirect

       Thaokar, C., Rabin, Y. (2011): Temperature field reconstruction for the application of wireless implantable temperature sensors in cryosurgery. ASME 2011 Summer Bioengineering Conference - SBC 2011, Farmington, PA, USA (June 22-25) ASME Digital Collection

       Khairi, A., Hung, S-C, Paramesh, J., Fedder, G., Rabin, Y. (2011): Ultra-miniature wireless temperature sensor for thermal medicine applications. Energy-based Treatment of Tissue and Assessment VI, SPIE – BiOS 2011, San Francisco, CA, USA (January 22-27) PubMed, HHS Public Access



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This research has been supported, in part, by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) NIH Grant # 1R21EB009370