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Ultra-Miniature Wireless Implantable Temperature Sensors
This
line of research focuses on the development of ultra-miniature wireless
implantable temperature sensors, for the purpose of evaluation and control of
thermal surgery. Thermal surgery is the destruction of cancerous tumors by
freezing (i.e., cryosurgery) or by heating (hyperthermia at
moderate temperatures and thermal ablation at higher temperatures).
Thermal surgery is a minimally invasive procedure, where its success is
dependent upon the ability to measure temperatures at critical locations and
reconstruct the temperature field in real time. The
goal in this line of research is to make temperature-field reconstruction in
real time a practical reality. The groundbreaking conceptual design of the
new temperature-sensing unit originates from recent advances in electronics fabrication,
miniaturization, and wireless communication. The sensing-unit consists of
three main components: a temperature-sensing core, a wireless transceiver,
and a power link. Below is a picture of a
0.1 mm × 0.4 mm CMOS temperature sensing core:
Selected
publications: •
Khairi,
A., Thaokar, C., Fedder, G., Paramesh, J., Rabin, Y. (2014): Characterization
of a CMOS sensing core for ultra-miniature wireless implantable temperature
sensors with application to cryomedicine, Medical Engineering and Physics,
36(9):1191–1196 PubMed,
HHS Public
Access, ScienceDirect
•
Khairi,
A., Wu, C, Rabin, Y., Fedder, G., Paramesh, J., Schwartzman,
D. (2013): Ultra-low power frequency and duty-cycle modulated implantable
temperature-pressure sensor. IEEE Biomedical Circuits and Systems Conference
- BioCAS 2013, IEEE, pp. 226-229, Rotterdam, the
Netherlands (October 31 – November 2) IEEE Xplore •
Thaokar, C.,
Rabin, Y. (2012): Temperature field reconstruction for the application of
wireless implantable temperature sensors in cryosurgery, Cryobiology
65(3):270-277 PubMed,
HHS Public
Access, ScienceDirect •
Thaokar,
C., Rabin, Y. (2011): Temperature field reconstruction for the application of
wireless implantable temperature sensors in cryosurgery. ASME 2011 Summer
Bioengineering Conference - SBC 2011, Farmington, PA, USA (June 22-25) ASME
Digital Collection •
Khairi,
A., Hung, S-C, Paramesh, J., Fedder, G., Rabin, Y. (2011): Ultra-miniature
wireless temperature sensor for thermal medicine applications. Energy-based
Treatment of Tissue and Assessment VI, SPIE – BiOS
2011, San Francisco, CA, USA (January 22-27) PubMed, HHS Public
Access
This research has been supported, in part, by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) NIH Grant # 1R21EB009370
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