The NIH funds 18 Common Fund programs — each generating valuable datasets, each with its own data formats, metadata standards, and portals. Individually, they’re useful. Together, they could be transformative. The Common Fund Data Ecosystem (CFDE) was built to make that integration real.
This preprint describes the evolution, architecture, and practical outcomes of CFDE: a collaborative infrastructure that links Common Fund programs and makes their data findable, accessible, and reusable across program boundaries.
The HuBMAP Data Portal is the public face of the Human BioMolecular Atlas Program — the place where the data actually lands and where the broader research community can access it. This preprint describes the portal’s architecture, capabilities, and current scale.
As of October 2025, the portal holds 5,032 datasets spanning 22 data types across 27 organ classes from 310 donors. That’s not a static archive: it’s a queryable, visualizable, analysis-ready resource.
