Senescent cells — cells that have permanently stopped dividing in response to stress — are a fundamental feature of aging, yet remarkably little is known about where they are, how many exist, or how they change across a human lifespan. The NIH SenNet Consortium was established to answer those questions at scale.
This Perspective lays out the goals, approach, and infrastructure of SenNet: a Common Fund initiative to comprehensively map senescent cells across 18 human tissues and build a publicly available atlas.
