HIV Viral Protease:


  Unmodified   Simple view
  
  
  Mut+cyclohexane  Drug 1  Drug 2  Drug 3  Drug 4

 

  Unmodified   Simple view
  
  
  Mut+cyclohexane  Drug 1  Drug 2  Drug 3  Drug 4
Instructions:
  • Clicking on "Unmodified" loads the structure for the non-mutated or unmodified enzyme in complex with a tight binding inhibitor that contains a cyclohexane group. Clicking on Mut+cyclohexane will load the structure of the mutant enzyme and the original (cyclohexane) drug.
  • Clicking on any of the buttons labeled 'Drug' loads the structure of the mutant enzyme with one of the particular drugs.
  • Clicking on "Simple View" shows the backbone atoms, the bound substrate in thick sticks+balls, and the sidechains of some important residues in thinner sticks.
  • Selecting "# 82 (grey)" will place a grey surface on the side-chain atoms of residue 82.
  • Selecting "Inh (green)" will place a green surface on the bound drug.
  • Selecting "Mod. Pep. Bond (red)" will place a surface over the atoms on the drug that would normally be a peptide bond.
  • Selecting "Cat. Asps (yellow)" will place a yellow surface over both active site aspartates (one from each chain).