Instructions:
- Clicking on "Unmodified" loads the structure for the
non-mutated or unmodified enzyme in complex with a tight binding inhibitor
that contains a cyclohexane group. Clicking on Mut+cyclohexane will load the
structure of the mutant enzyme and the original (cyclohexane) drug.
-
Clicking on any of the buttons labeled 'Drug' loads the structure
of the mutant enzyme with one of the particular drugs.
- Clicking on "Simple View" shows the backbone atoms, the bound substrate in
thick sticks+balls, and the sidechains of some important residues in thinner sticks.
- Selecting "# 82 (grey)" will place a grey surface on the side-chain atoms of residue 82.
- Selecting "Inh (green)" will place a green surface on the bound drug.
- Selecting "Mod. Pep. Bond (red)" will place a surface over the atoms on the drug that would normally be a peptide bond.
- Selecting "Cat. Asps (yellow)" will place a yellow surface over both active site aspartates (one from each chain).
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