•We are interested in the role of
surface interactions in Ab aggregation.This question is especially relevant, given that the intra- and extra-cellular environments are highly
congested and heterogeneous.
•We are studying this problem through
direct in situ tapping mode AFM observations of
various model surfaces
remaining in contact with physiological solutions of Ab.
Shown here is the course of Ab
aggregation in contact
with the hydrophobic surface of highly oriented pyrolitic graphite (HOPG).HOPG can be viewed as an analog of biologically hydrophobic environments such as
interior of lipid bilayers or
In contact with HOPG surface, Abforms elongated, flat sheets which form raft-like assemblies.Interestingly, all sheets and rafts tend to be oriented along three preferential directions.