Biochemistry I   Spring & Fall Terms

Super Secondary Structure Motifs: b-Sandwich Proteins

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  Load these "Sandwiches"
  (1TTA)
  (1NLS)
  (1SLT)
  (1KIT)
  (1AMX)
  (1TEN)

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b-Sandwich Structures Gallery
The b-sandwich class of proteins are characterized by two opposing antiparallel b-sheets in their structures. They differ in the number of strands found in the sandwich motif and in the extent to which a-helices and other structures are present. The similarities and differences can be seen by viewing these six examples:
PDB ID Protein (Other Features)
1TTA Human Transthyretin
(Greek key topology)
1NLS Concanavalin A
(Jelly roll topology)
1SLT S-Lectin (A Vertebrate 14 Kd b-Galactoside Binding Protein)
(Lectin binding domain)
1KIT Vibrio cholerae Neuraminidase
(Two Lectin binding domains + b-propeller)
1AMX Staphylococcus aureus Adhesin (Collagen-Binding Domain)
(Jelly roll topology)
1TEN Tenascin (Third Fibronectin Type III Repeat)
(IgG-fold; aka "immunoglobulin module")
The above listing also shows that these proteins perform a wide variety of functions in diverse organisms.
Viewing Tips:
1. Color the displays by Group to see the course of the polypeptide chain from N- to C-terminus.
2. Several of these proteins have important ligands and/or prosthetic groups; you can visualize them by selecting Ligand (under Hetero), followed by Spacefill, and then CPK.

Back to the Protein Structure List.

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8.21.04