Biochemistry I   Fall Term, 2002

Triose Phosphate Isomerase (TIM): PS#3 Answers
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  Highlight PS#3 Answers:
  1a. b-strand H-bonds
  1b. a-helix H-bonds
  2. Hydrophobic Residues in the a-helix
  3. Charge Interaction
  4a. Solvent-exposed Hydrophobic Residue
  4b. Cys 41 side chain contacts (CPK)

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  The First bab motif of Triose Phosphate Isomerase (TIM)
Images related to the answers for Problem Set #3 Fall, 2002:
(Buttons 1-3 above display only residues 2-42 of TIM).
1a. Donors, acceptors and H-bond distances between the b-strands.
1b. Donors, acceptors and H-bond distances in the a-helix.
2. Four hydrophobic residues (Ball & Stick, green) in the a-helix that extend into the region between the helix and the sheet and their van der Waals contacts (Atoms within 5 Å shown as Sticks, colored green).
3. A likely possibility for a favorable charge interaction between two residues in the first bab motif of TIM.

4a. Solvent-exposed hydrophobic residue in the first bab motif. (Hydrophobics are green):
    PRO 33 (Ball & Stick) is mostly exposed to solvent.
    PHE 5 (Ball & Stick) is partially exposed.
4b. The interactions made by the Cys 41 side chain that contribute to the tertiary structure of TIM. (Atoms within 5 Å of the Cys 41 side chain are colored CPK).

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9.18.02