Feedback for Multiple Choice Quiz 37

  1. The bacterial RNA polymerase subunits are described by Campbell on p. 264; the eurkaryotic enzyme is described on p. 278.

  2. The promoter was originally defined in genetics as the site of a certain class of mutations. The defining characteristics have been refined by DNA sequencing and biochemical studies.

  3. Repressors generally compete with RNA polymerase for overlapping sites (operator and promoter, respectively) near the startpoint of transcription.

  4. The fidelity of transcription (~10-4 error frequency) matches the average fidelity of translation. These are both much lower fidelities than that found in DNA replication.

  5. The initial binding of RNA polymerase to the promoter generates the closed complex. The system is not yet committed to RNA polymerization.

  6. Normally, transcription is terminated when a rho site is passed. RNA polymerase is a very processive enzyme, so it never falls off of the DNA until told to do so. The stop codon halts protein synthesis, not mRNA production.
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