Feedback for Multiple Choice Quiz 7 #2

  All of the correct answers have a green check mark.
  Incorrect answers have the "red-lit" button next to your choice.
  1. At Tm, the midpoint of a cooperative unfolding reaction, each of the four statements imply the other three.
  2. A positive DH means that unfolding is disfavorved enthalpically; hence, folding is favorved enthalpically.
  3. Most small proteins (and the domains of larger proteins) are only moderately stable to unfolding under physiological conditions. Stability does not correlate with size. Details of the separate contributions from DH and TDS cannot be deduced from DG values alone.
  4. A conceptual argument for the correct answer is that burial of side chains in the hydrophobic core of proteins during folding is similar to their transfer into an organic solvent in the lab.
  5. The very essence of chemical coupling is that the two reactions are linked and treated together energetically, i.e. the DG values are added.