Our work is unified under one theme: the engineering of synthetic biological systems for therapeutic treatment. We approach this issue through two fundamental directions. To improve the control of synthetic cellular systems, we harness functioning mechanisms in natural cells to control dynamics of synthetic cells and organisms. In parallel, we investigate how heterogenous cellular populations respond to drug treatment. We aim to merge the two directions to create novel treatment strategies using artificial cellular systems. We are honored to work with biologists, statistician, engineers, physicist, and chemists in the pursue of our research goals. Our work is multi-disciplinary and strives to create new frontier in synthetic & quantitative biology by synergizing ideas from different fields.
Shaping gene expression in artificial cellular systems by cell-inspired molecular crowding.
C. Tan, S. Saurabh, M. Bruchez, R. Schwartz, and P. LeDuc. Nature Nanotechnology, 2013 pdf
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