Study of Cellular Dynamics
I am interested in understanding the mechanisms of cellular dynamics in the vicinity of topological constraints. I believe that by providing a synthetic fibrous environment with artificial topological constraints mimicking the extra-cellular matrix can yield crucial information on cellular behavior. As shown in images, cells seeded on intersecting fibers are observed to make right angle transitions and upon encountering diverging fibers, their motion is thwarted.
"Use of images is only allowed with permission"
Peer Reviewed Publications:
A.
S. Nain, J. A. Phillippi, M. Sitti, J. MacKrell, P. G. Campbell and C. Amon,
“Control of Cell Behavior by Aligned Micro/Nanofibrous Biomaterial Scaffolds
Fabricated by Spinneret-based Tunable Engineered Parameters (STEP) Technique”,
Small, 2008 (accepted for publication
with minor revisions)
Publications under Preparation:
A. S. Nain, B. Behkam, E. Miller, P. G. Campbell and C. Amon, “Achieving directed Cellular motion on Aligned Fibrous Scaffolds”, to be submitted to Biomaterials.